Centrophenoxine is an anti-aging drug widely used in Europe to
increase brain energy. Centrophenoxine stimulates chemical activity of the brain,
in particular the uptake of glucose is increased. Glucose is essential for energy
production; oxygen consumption and carbon dioxide production also increase significantly
when centrophenoxine is taken regularly.
Centrophenoxine has
also been found to be very effective in the treatment of various human disorders,
such as brain damage due to old age, stroke, brain injury caused by chemicals
or drugs including excessive alcohol consumption. Centrophenoxine has the ability
to protect against the damage caused by modern toxic environmental chemicals. Protection
Against Aging
Prolonged administration of Centrophenoxine has been given to
healthy old animals, and caused a large reduction in the lipofuscin present in
heart and brain cells. Lipofuscin is a waste product that builds up in older cells.
The life span of Centrophenoxine treated animals is much longer than that of animals
that did not receive the drug. The learning ability of the
treated animals was also much greater than the untreated animals. Centrophenoxine
is able to reverse the age dependent accumulation of the mineral potassium in
brain cells, and a number of other damaging changes that occur as the brain ages.
Centrophenoxine increases the production of chemicals that are essential for the
proper functioning of the brain, such as RNA and protein. Glucose uptake into
the brain is also increased, in spite of the evidence of the effects of Centrophenoxine,
its workings are not quite clear. Centrophenoxine has played
a central role in many anti aging experiments, and there is strong evidence supporting
the observation that vital membranes are protected during continuous treatment
with Centrophenoxine. It provides protection against free radical
damage caused by aging and improves the body’s defense against free radical
attacks .Centrophenoxine has been revealed in many scientific experiments to reverse
the decrease in RNA. RNA is essential for the body to produce protein and decreases
with increasing age, as Centrophenoxine increases RNA supplies this leads to an
increase in
protein turnover, this is beneficial in anti-aging. Memory
Loss and Senile Dementia
Centrophenoxine has been found to be most
useful in the treatment of senile dementia. Regular use of Centrophenoxine offers
a chance to prevent mental deterioration because mental performance is improved
in both the healthy individual and those with senile dementia Experimental studies
have shown that Centrophenoxine reduces the amount of lipofuscin in nerve cells. This
suggests that mental function is enhanced by the removal of lipofuscin from the
nerve cells. Senile dementia is related to changes in the part of the brain
responsible
for memories; the hippocampus. The nerve cells of the hippocampus are damaged
as part of the aging process, however in senile dementia the damage is far greater.
Similar changes also occur in other parts of the central nervous system. A very
important effect of Centrophenoxine is the stimulation of uptake of glucose by
the brain, this can make up for the damage caused to the hippocampus by aging
and senile dementia. The beneficial effects on mental performance seen in people
following regular use of Centrophenoxine are due to a real improvement in the
efficiency of the workings of the vital cells. Nerve cells
work much better under the influence of Centrophenoxine. The exact way that Centrophenoxine
works is not clear, but a theory has been elaborated by Professor Imre Zs.-Nagy
and titled the “membrane hypothesis of aging”. This theory attributes
a primary role in aging to a decrease in the ability of the mineral potassium
to get into and out of cells. This causes the level of potassium
in the cell to rise leading to a reduction in essential protein production. The
increased potassium levels are due to free radical induced crossed linking in
the cell membrane. The cells of the body gradually lose their ability to eliminate
damaged components, i.e. lipofuscin slowly builds up in the cells. Centrophenoxine
slows down the rate of accumulation of age deposits and is incorporated into the
membranes of the brain cells, where it protects against the cross linking effects
of free radicals. Centrophenoxine is able to increase the storage of new information
in long term memory and increase mental alertness.
Dosages
and Side Effects
There has been no toxicity associated with Centrophenoxine
in therapeutic dosages. Normal dosages are one or two 250mg tablets a day, unless
suffering from senile dementia then 4x 250mg tablets are taken throughout the
day. However, it is advisable to take occasional breaks, the
appearance of muscle aches and pains may be a sign of over-dosage and thus a reduction
in dose is required. Persons who suffer from severe high blood pressure, convulsive
disorders such as epilepsy as well as children, pregnant or lactating women should
not use Centrophenoxine, it is most popularly known as the trade name Lucidril. Centrophenoxine
(1)
Vojtechovsky M: “Int J psychobiol” 1 49-56
(2) Glees P, Hasan M:
“ Lipofuscin in neuronal aging and diseases”
47 48 Thieme Verlag.
(3)
Hochschild R: “Exp Geront” 6 153-166 1971.
(4) Zs Nagy I “Arch
Gerontol Geriatr” 3 297-310 1984.
(5) Marcer D: “Age and aging”
6 123 1977.
(6) Zs Nagy I “J Theor Biol” 75 189-196 1978.
(7)
Zs Nagy I “Mech aging Dev” 9 237-246 1976
(8) Nandy K: “Nature”
210 313-314 1966.
(9) Nandy K: “J Gerontol” 23 82-90 1968.
(10)
Herrschaft H: “Dtsch Med Wschr” 99 1707-1714 1974.
(11) South J “The
brain booster” anti-aging Bulletin, Volume 3
Issue 1 March 1997 Internationsl
Anti-Aging Systems.
(12) Zs Nagy I “Membrane theory of aging, centrophenoxine
and its
developments.” 1st Monte Carlo anti-aging Conference, June
2000.
| 
