Hydergine-the Most Popular Ergot
Now we move onto one of
the most popular and widely used smart-drugs that has been in use for over 40-years-
Hydergine (pronounced hi-der-gene).
Hydergine has received
only mild reviews whilst being used to treat senile dementias, (although
it is widely regarded to have been used in dosages that were far too small for
those purposes). However, hydergine presents itself as a remarkable anti-aging
medicine and an adjunct for the treatment of age-related mental decline.
is known to have all the following effects:
1. Increase blood supply
to the brain.
2. Increase oxygen delivered to the brain.
3. Enhance metabolism
of brain cells.
4. Protect the brain from insufficient oxygen supply.
Slow the deposit of the age pigment lipofuscin in the brain.
6. Prevent free
radical damage to brain cells.
7. Increase intelligence, memory, learning and
Oxygen is unique in that it is both a free radical
generator and a free radical scavenger. At optimum concentrations, oxygen neutralizes
more free radicals than it produces. Either too much or too little can upset the
balance and generate the production of free radicals, which in turn can lead to
aging. One of the major ways in which oxygen generates free radicals is its reaction
with unsaturated fats, a process called peroxidation.
our brain cells contain more unsaturated fats than any other part of the body,
therefore it is our brains that are most susceptible to peroxidation. Here are
some conditions that can cause major peroxidation and the formation of massive
amounts of potent free radicals:
A. Heart attack
Pollution (Carbon monoxide greatly reduces the oxygen carrying ability of the
D. Smoking cigarettes (Nicotine constricts blood vessels and decreases
oxygen supply to the brain. It is estimated that those who smoke more than 20
cigarettes a day lose at least 7% of the normal blood flow to the brain).
European countries use hydergine for emergencies and accidents that involve shock,
haemorrhage, strokes, heart attacks, drowning, electrocution and drug over-dose.
Hospitals give hydergine to patients before an operation in order to gain time
in case of any ensuing crises. This is because hydergine helps to stabilize brain
oxygen levels, if they are too high hydergine lowers them, if they are too low
then hydergine improves them. This was graphically illustrated in a cat experiment.
groups of cats were anaestheized and their brains electronically monitored. The
scientists reduced the brains blood supply (and therefore oxygen supply).
The cats in the control group (i.e. no hydergine) had brain damage within 5-minutes
and died within 15-minutes. However, the cats in the prehydergine treated group
had strong brain wave patterns up to 45-minutes later. This
two things, firstly that a decrease in the normal oxygen balance results in tremendous
free radical damage and secondly that hydergine protects against this free radical
damage when the oxygen level is upset.
Hydergine has also been
shown to increase the level of neurotransmitters in the brain, whilst this may
not be significant enough for the treatment of senile dementia, such action has
implications and benefits for the treatment and prevention of agerelated mental
There is also evidence that hydergine stimulates the
growth of dendrite nerve fibres. Dendrites can normally be expected to decline
with aging and some scientists have associated the number and density of dendrites
This decrease in brain cell connection has
been hypothesized to be due to an impairment in the energy supply at synaptic
regions. Because of hydergines known ability to improve nerve cell metabolism,
a group of Italian scientists studied the ultra-cellular features of synaptic
mitochondria to see if long-term hydergine treatment could delay or prevent the
loss of synaptic connections.
The mitochondria are the intracellular
powerhouses where the universal energy molecule-ATP (adenosine triphosphate)
The scientists found that the number of mitochondria
are greatest at about 12-months of age in rats (equivilant to a 25-year old in
human terms) and then progressively decreases. However, the size of the mitochondria
increased progressively after 12 months. Thus in young adult rats, the energy
required at synaptic regions is provided by a large number of small, highly efficient
mitochondria, whereas in old rats, energy is produced by a smaller number of larger,
less efficient mitochondria.
But, astonishingly after treatment
with hydergine, it can be seen that the total mitochondrial volume of old rats
was nearly the same as the young rats. Furthermore, the mitochondrial size was
altered to a more youthful direction
Like its ergot relatives,
hydergrine has also shown itself to be a mild vasodilator (it enhances brain blood
flow) and improves the uptake of the brain energy molecule glucose. Hydergrine
also reduces the accumulation of age-related toxin, lipofuscin.
and again, clinical trials indicate that hydergrine can improve cognitive functions,
mental alertness, clarity and mood.
Dosages, Side effects
With literally thousands of published clinical research
papers and hydergrines decades of use around the world, it has proven itself
to be non-toxic and relatively safe. Its potential side effects include mild nausea,
gastric disturbances and bradycardia. It should be avoided by people who suffer
from psychosis, or those with low blood pressure or abnormally slow heartbeat.
Seek a health professionals advice if combining hydergine (at dosages in
excess of 9mg per day) with other ergot derivatives or vasodilators.
people do well at dosages of around 2.25 mg to 4.5mg per day with occasional breaks.
The most common side effect of stomach upset can be avoided with the use of specially
coated tablets (known as FAS) or sublingual liquid versions.
its beneficial affects, mild side effects and few contraindications, hydergine
is ranked as one of the most important anti-aging medicines available today.
from rye were used by our ancestors for many different reasons, some of them as
rites of passage into adulthood, most were considered to be mind-expanding.
Now we know many of the pharmacological actions and roles they play in mental
and memory enhancement and in the slowing of age-related brain disorders.
we understand that brain protection and enhancement is a most important factor-
if not the most important factor for antiaging medicine and successful longevity.
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"My writer's block has gone and I have accomplished
more work in the last month than I achieved in virtually all of last year! This
has been happened in the several weeks that I have been using Hydergine, I don't
believe this is a coincidence." S.K.,
Ditch M, An ergot preparation in the treatment of Cerbrovascular disorders
in the geriatric patient Journal of the American Geriatrics society (1971)
19 No3 208-217.
(2) Sandoz Inc., Hydergine Manufacturers product
information sheet (1999).
(3) Hughes J, An ergot alkaloid preparation
in the treatment of dementia Journal of the American Geriatric society (1976)
(4) Cranton M: Franckelton J: Treatment of free Radical pathology
in chronic degenerative diseases with EDT chelation therapy Journal of Holistic
Medicine (1984) 6-1.
(5) Rao B: Norris J: A double blind investigation
of Hydergine in the treatment of cerebrovascular insufficiency in the elderly.
John Hopkins Med. Jour. (1971) 130 317-23.
(6) Fanchamps A, Dihydroergotoxine
in senile cerebral insufficiency aging (1983) 23.
(7) Hindmarch I, The
effects of an ergot alkaloid derivative on aspects of psychomotor performance
the journal of clinical pharmacology (1979) 726-731.
(8) Spiegel R, A
controlled long term study with Hydergine, in healthy elderly volunteers
Journal of the American Geriatrics society (1983) 31, No 9 549-555.
C, Fattoretti P, Casoli T, Spanga C, Meier-Ruge W, Morphological alterations
od synaptic mitochondria during aging-the effect of hydergine treatment in the
pharmacology of the aging process-methods of assessment and potential interventions.
New York Academy of Sciences,
volume 717 by Imre Zs-Nagy and Kenichi Kitani
eds.) NYAS, Ny 1994.
(10) Cucinotta D, Deleo D, Frattola L, Trabucchi M, Parnetti
L, Dihydroergokryptine vs. placebo in dementia of Alzheimer type: Interim
study after a 1 year follow up. Archives of Gerontology and Gieriatrics,
22, 169-180 (1996).
Ingredients and Applications
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