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TI-Melatonin®: Biological effects and scientific information:
TI-Melatonin® expresses the best imaginable melatonin preparation available on the world-market and is now available as a food additive and dietary supplement to anybody wanting to take advantage of the extraordinary scientific observations of Dr. Walter Pierpaoli and his co-workers. The basic experimental findings of 35 years of research, resulted in the discovery of the undeniable existence of a programmed "Aging Clock" in the pineal gland complex of the brain. We have investigated the possible mechanisms and also the molecules which presumably cooperate and synergize with melatonin in the regulation and re-synchronization of the fundamental immunological and hormonal functions, (which are normally lost or deranged in the course of aging). In recent studies and long-term experiments with old rodents it has been observed that zinc can completely correct aging-dependent immuno-depression and several other hormonal and metabolic alterations typical of aging. It has been found that the low zinc levels in aging animals can be restored to normal values with nocturnal administration of melatonin or transplantation of the pineal gland from young animals into older animals6-9. Zinc is an essential component of more than 200 enzymes and one of the most relevant trace elements in the body8,9. It is therefore clear that additional zinc must be supplemented daily to the body of an aging organism with a low zinc balance, in-order that melatonin can better exert its anti-aging activities on the entire neuroendocrine and immune systems! This important and novel scientific observation of the powerful anti-aging and immuno-enhancing activity of the combination of zinc and melatonin has now resulted into the development of TI-Melatonin®. Furthermore, selenium is a fundamental trace element of the body and possesses powerful anti-cancer effects. But modern agriculture and alimentary habits have dramatically decreased the daily input of selenium from the diet. Selenium is essential for the enzymatic reaction responsible for the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage. A lack of selenium will thus result in a loss of the detoxification capacity of the body, immuno-depression and onset of degenerative diseases and cancer10. This is the reason why TI-Melatonin® combines, (in a unique synergistic combination), the three fundamental anti-aging molecules of melatonin, zinc and selenium. Whilst melatonin plays the master role for reactivation and restoration of its natural night peak to juvenile levels, (this resulting into normalization of all measurable immunological and endocrine functions in the course of aging), the positive age-postponing, metabolic and immunological effects of TI-Melatonin® can be measured easily by anybody with a normal periodic check-up! These restoring metabolic changes will become progressively more visible and remarkable over the course of years, after initiation of the treatment with TI-Melatonin®. Further studies are now in progress and they will allow us to progressively add more elements suitable to further improve and accelerate the rejuvenizing effects of nocturnal melatonin. But the "programme of aging" can be slowed down now to a more acceptable rate with regular nocturnal use of TI-Melatonin®.

TI-Melatonin®: Composition of active components in each tablet:
Melatonin (N-acetyl-5-methoxytryptamine), 3mg, synthetic, certified purity: (99.9 % (HPLC), Zinc-orotate x 2H2O, 50mg corresponding to 8.7mg zinc. Selenium, 50mcg, from sodium selenite pentahydrate. TI-Melatonin® is produced in Switzerland in compliance with the severe international rules of Good Manufacturing Practise (GMP) and under licence of Swiss Health Authorities.

Contraindications and general suggestions:
TI-Melatonin® should not be given to healthy children, pregnant women and lactating mothers unless specifically prescribed by a physician. There is no evidence that TI-Melatonin® could adversely influence the effects and activity of estrogens. On the contrary, melatonin increases the density of estrogen receptors in sensitive target tissues (mammary gland, womb, ovaries, etc.) and greatly improves their actions. There are no contraindications for dietary supplements containing melatonin, zinc and selenium. No ascertained, life-threatening, acute or moderate, short- or long-term side-effects have been scientifically demonstrated or reported. Melatonin must be taken late in the evening at bedtime in order to mimic and restore the physiological night peak, which normally declines progressively during the course of aging. As mentioned in the literature reported above, the progressive abrogation of melatonin night-cyclicity during aging is considered to be a basic signal expressing the extinction of the most fundamental regulatory system in the body. This brain "clock" is genetically and evolutionary linked to the sun, the planetary system and the obvious dependence of our health from daily and nocturnal, rhythmic cyclicity. Every person expresses their own genetically inherited nocturnal peak of melatonin, with very large individual variability. However, in the majority of the population, the night elevation of melatonin declines and most of us become "flat" after 80 years of age. This is a basic aging message from the "clock"11. The dosage of melatonin is still rather empirical and based on animal and human studies. The blood night level generated by 3mg by far exceeds the normal night levels of healthy young persons. However, melatonin is rapidly metabolized and excreted by the kidneys with no consequences. Use of beta-blockers in the evening may abrogate the night peak of melatonin. If they must be taken, it may be necessary to take them in the morning or to increase the dosage of melatonin. Circadian, night melatonin seems to produce a resynchronization of the entire neuroendocrine system and will certainly improve metabolic and hormonal functions, including blood pressure, cholesterol levels, thyroid, gonadal and adrenal functions. These effects can be easily evaluated with a routine check-up. Melatonin will counteract the negative side-effects of cortico-steroids and of di-stressful agents, thus protecting the immune system. Melatonin does not induce sleep but facilitates its onset and produces a sleep pattern which is typical of children or young persons. It greatly improves the quality of sleep and its restoring physical and psychological effects, with a clear improvement of morning mood and body muscle strength. Melatonin is not a drug and it is not itself a cure for any disease! Melatonin is ubiquitous in nature, cells, plants, animals, tissues and any living organism. Milk, vegetables, cereals, rice, meat, etc., contain variable amounts of melatonin. Synthetic melatonin could be theoretically replaced by alimentary melatonin in the daily food, but its replacement would be problematic and difficult to achieve for everybody. Melatonin produced by the pineal gland seems to be responsible for the night peak, while melatonin produced by the gut and the retina does not seem to affect the nocturnal levels. It is thus evident that the night peak of melatonin initiates a sequence of positive effects with a cascade of events which maintain the body systems synchronized with the physiological cyclicity of hormones and cells. This night "signal" is essential for the maintenance of immunity and the "surveillance" against the onset of tumors. Therefore melatonin is a fundamental element for prevention of aging-related diseases, including cancer, autoimmune and cardiovascular diseases. Melatonin cannot be considered a classical "hormone," although it is so-named. It does not possess any of the qualities of the classical hormones like growth hormone, cortisol, estrogens, thyroid hormones etc. It is rather a chemical mediator whose mechanism is still unknown. It modulates and controls the synthesis and secretion of all hormones within a circadian and seasonal periodicity and variability. It has been given at a huge dosage of grams daily for prolonged periods, and to 1500 women at the daily dosage of 300mg for years with no observed late side-effects and consequences. The administration of melatonin to restore the physiological adaptation of the body to circadian and seasonal periodicity is only the beginning of a new medicine based on the concept that nobody can escape the established laws of Nature within the solar-planetary system, in which man developed as a mammalian species. We must be able to restore and correct the derangements of this adaptation system and maintain it in its original juvenile conditions. These metabolic conditions can be perfectly measured and maintained under balance, not with a cumbersome and complex hormonal supplementation (e.g. testosterone, growth hormone, pregnenolone, etc.), but with a correction of the central regulatory system located in the "pineal complex" (pineal gland and the many anatomical and functional connections in the brain and the neuroendocrine-immune systems). TI-Melatonin® is perfectly suitable to re-synchronize all neuroendocrine functions. TI-Melatonin® contains basic elements which will synergize in order to obtain more rapid effects and to compensate the loss of fundamental minerals, due to a wrong diet or to aging. The beneficial effects of melatonin in the normalization of zinc levels have been scientifically proven and constitute a basic tool for maintenance of hormonal and immune functions and to restore these functions during aging.

Common agents which antagonize synthesis and secretion of melatonin:
Alcohol, cortico-steroids, beta-blockers (especially in the evening), caffeine, nicotine and many chemical substances with pharmacological activity can antagonize the synthesis and secretion of Melatonin. But melatonin does not itself antagonize the activity of any drug and can be used in combination with any medical drug and pharmaceutical specialty. Nocturnal melatonin will in-fact improve the effectiveness and activity of drugs as a consequence of its synchronizing properties on the entire neuroendocrine and immune systems.

TI-Melatonin®: Suggested daily dosages as a dietary supplement:
Between 40 and 50 years of age: 1.5mg to 3mg at bedtime (peremptorily at the same hour, with half an hour tolerance). After 50 years until 75 years of age: 3mg at bedtime- as above. From 75 years of age: 3-6mg at bedtime- as above. Although not mandatory, it is indicated to take TI-Melatonin® for 5 months in summer (May-June-July-August-September) and for 5 months in winter (November-December-January-February-March). TI-Melatonin® can be safely taken without intervals after 50 years of age, in the presence of chronic, degenerative diseases and cancer, or as a protective agent under stressful conditions (night-work, exposition to poisons and noxious agents, time-zone travel etc.). It is strongly recommended to take TI-Melatonin® for periods of weeks before and after surgical interventions to ameliorate general conditions (mood, immunity, etc.) and to accelerate immunological reconstitution, wound healing, tissue regeneration and recovery from anesthesia toxicity after the operation. For jet-lag we suggest taking 3mg of TI-Melatonin® for four to five days at 10-11 PM, local time, on arrival at the place of destination and to repeat the same procedure after returning to the original place of departure.

Keep this and all other medicines safely out of the reach of children.

Product SKU Price Type Weight
Prescription Needed
Discreet Mail
Melatonin (Oral) MELAT-1-IAS
Tablets 60x3mg
Melatonin (Oral) MELAT-2-IAS
Tablets 60x10mg
Melatonin (Liquid) MELAT-2-IAS
Liquid 1oz 90mg
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