This hormone is excreted by the
pineal gland during sleep, and Melatonin production has been shown to decline
as we age. Click here to see a figure depicting the decline of Melatonin levels
with advancing age. Melatonin's main use has been shown to regulate sleep and
circadian rhythmns, and allow the individual to feel more refreshed and alert
the following day. As melatonin is directly involved with sleep regulation, the
supplement's use in the treatment of age-related sleep disorders, jet lag or shift
work is impressive. Furthermore, Melatonin has also been shown to improve the
condition of Seasonal Affected Disorder (SAD) and extend the life span of animals.
Melatonin is also considered to be a potent antioxidant. Recent evidence by Walter
Pierpaoli MD, (the originator of Melatonin and the author of the best selling
book The Melatonin Miracle), indicates that Melatonin protects the pineal gland.
In fact, Dr. Pierpaoli believes that the role of Melatonin is specifically to
protect the pineal gland against aging. Certainly, the pineal gland is unique,
(in that it isn't protected by the Blood Brain Barrier, unlike most of the brain),
and Dr. Pierpaoli asserts that Melatonin helps to reset the pineal, which in turn
helps to reset the endocrine system and thus maintain a 'youthful' hormonal balance
and regulatory cycle. Dr. Pierpaoli's and Professor Vladimir Anisimov (see Monte
Carlo Anti-Aging Conference June 2001) and others, are working hard on discovering
the actions of existing (and indeed new!) pineal and hypothalamus hormones. But
they already agree on one thing; They concur that pineal and hypothalamus hormones
have potent anti-carcinogenic affects and due to their hormonal resensitizing,
that they have a 'rejuvenating' affect upon the whole organism. For these reasons
Melatonin is considered to be a most important anti-aging substance. Whilst "general"
Melatonin supplements have become widely available, IAS has now decided to offer
a specific type that has been especially formatted by Dr. Pierpaoli himself. It's
called TI-Melatonin® and it is a pharmaceutical grade Melatonin bonded with
selenium and zinc. These substances work synergistically with Melatonin and produce
a much greater affect. Dr. Pierpaoli is now writing an article for the Winter
2001 Issue of the IAS Anti-Aging Bulletin. He intends to elaborate on his new
work with Melatonin and explain why TI-Melatonin® is the most effective Melatonin
available anywhere in the world today. Currently, TI-Melatonin® is only registered
in Italy, Switzerland and Kenya and thus IAS is pleased to announce that we are
now carrying this important supplement. After our own personal use, we can clearly
state that TI-Melatonin® is significantly different and much more potent (mg/
mg) than any other form of Melatonin we have tried (oral or sublingual). Therefore
in keeping with the IAS policy of always stocking the best that is available,
we have decided to offer TI-Melatonin® at this time. If you've tried other
Melatonin's and decided there wasn't much effect, we urge you to try TI-Melatonin®.
Dosages are half to one (maximum two) 3mg tablets at bedtime only. Only use TI-melatonin®
when you are prepared to sleep.
All Prices are subject to change based on the latest prices from IAS
"found that the difference with TI-Melatonin® is very
substantial. Normally I have to take at least 9mg of other Melatonins to aid my
sleep, but I found that 3mg of TI-Melatonin® was much more effective. So much
so, that I am now only using half a tablet!" Phil Micans, PharmB.
represents a breakthrough in the use of Melatonin supplements; call it genius
or luck, but my patients are now obtaining excellent results with it!" Walter
"TI-Melatonin® is without doubt the most
effective Melatonin I've ever used. Normally I haven't noticed any strong sleep
enhancement effects with other types, but TI-Melatonin® almost knocks me out!"
David Butler BSc