Piracetam is an intelligence booster, and CNS (central nervous system) stimulant
with no known toxicity or addictive properties.
has been described by many people as a drug that wakes up your brain.
Piracetams effect and safety have been so impressive, that it created a
new classification of drugs called Nootropics.
The term Nootropic
is Greek and means acting on the mind. Since the creation of Piracetam
by Dr. Giurgea in 1966, many pharmaceutical companies have been very busy developing
Even though Piracetam has been available in parts
of Europe since the 1960s there are currently no FDA approved Nootropic
drugs in the United States.
has a very similar molecular structure to the amino-acid pyroglutamate, and they
share the same base chemical structure.
cognition under conditions of hypoxia (too little oxygen) and improves memory
and learning abilities in normal people. In Europe, piracetam is used to treat
alcoholism, strokes, virtigo, senile dementia, dyslexia and numerous other health
Another of piracetams action is to promote
the flow of information between the left and right hemispheres of the brain through
the corpus callosum. It is known that communication between the two hemispheres
is responsible for creativity, this may be the reason for piractams usefulness
in the treatment of Dyslexia.
can aslso be enhanced by using DMAE, Centrophenoxine, Choline, Hydergine and Vinpocetine,
the synergistic effect causes a greater improvement in memory, than any one taken
One study has
suggested that piracetam increases the numbers of receptors in the brain. Aging
causes a decline, but Alzheimers disease causes a rapid decline in intellectual
function, which is partly due to a decreased cholinergic system, caused by cell
death and degeneration.
In a test on older mice, some were
given piracetam for only 2 weeks and the density of cholinergic receptors in the
frontal cortexes were measured. The researchers found 30% to 40 % higher density
of receptors than in the control group.
Piracetm unlike any
other drug, appears to have a regenerative effect on the central nervous system.
Dosages and Side Effects
Piracetam can increase
the effects of other drugs, such as amphetamines and psycotropics. Adverse effects
are very rare, but include nausea, gastrointestinal distress and headaches. This
is typical of the synergy present with piractam and its analogues, overall dosages
of other nootropic and brain drugs may need to be reduced.
has no known toxity.
Piractam is supplied in 400mg, 800mg,and
1200mg tablets, the total dose is usually 1600mg to 3600mg daily. Some literature
recommends a high dosage for the first two days (up to 6000mg), then to resume
a normal dosage level. Piracetam normally takes effect within 60 minutes.
The standard dose is usually 2500mg twice a day for the first month,
reducing to 1200 mg twice a day thereafter.
is now nearly four decades since piracetam became commercially available.
that time a number of analogues have been discovered and developed. These include
Aniracetam, Modiracetam, Oxiracetam and Pramiracetam.
the anologues have been shown to be more potent than piracetam in clinical trials.
In all cases the analogues have been shown to be twice as potent and some trials
up to 7 times as potent.
Most physicians agree, the use of
nootropics is both individually sensitive and bodyweight relative.
nearly all cases, some experimentation with both the nootropic and its dosage
is required to discover which one works best and at what level.
one can create a synergistic affect with others that have different actions, such
as centrophenoxine or hydergine. However, when combinations of such smart-drugs
are taken together it is necessary to reduce the dosage of each (compared to the
dosage that would be taken if one product was taken alone).
fact is that Piracetam improves verbal learning and appears to be a substance
capable of extending the intellectual functions of man, even individuals already
gifted with high intelligence and good memory". S.J. Dimond, E. Brouwers
in the power of human memory in normal man through the use of drugs" Psychopharmacol.
49, 1976, 307-309.
(1) Bartus RT: profound Effects of combining Choline
and Piracetam on memory enhancement in aged rats Neurobiology of aging V2
(2) Diamond S: browes E: Increase in the power of human
memory in normal man with the use of drugs psychopharmacology V49 p307-309
(1) Ferris SH: Combination of Choline and Piracetam in the treatment
of senile dementia psychopharmacology Bulletin V18 p94-98 1982.
E: Clinical response to choline plus Piracetam in Senile Dementia
the New England Journal of Medicine No 24 304 p1490-1491 1981.
CE: The Nootropic approach to the pharmacology of the integrative activity
of the braib Conditional Reglex V8 No 2 p108-115 1973.
(4) Giurgea CE:
Nootropic drugs progress in Neuropsychopharmacology V1 p235-247 1977.
Kent S Piracetam increases brain energy Anti-aging News V2 No 10 p65-69
(6) Mindus P: Piracetam induced improvement of mental performance
ACTAN psychiatrica Scandinavia V54 p150-160 1976.
(7) Pelton R: Pelton
T: Mind food abd smart pills New York Double day 1989.
G: Spignoli G: Neurochemical actions of Nootropic drugs Sdvances in
Neurology V51 Alzheimers disease New York Raven Press 1990.
B: New Pharmacologic perspectives on Nootropic drugs: Handbook of psychopharmacology
p11-18 p24-25 1988.
SUMMARY ABOUT SELECT PIRACETAM (PDF Format)
note that it is required that you have Acrobat Reader installed on your system
to view the above documents.
You can download the latest version by clicking